Endocrine Abstracts

Follistatin like 3 (FSTL-3) is an endogenous inhibitor that binds and inhibits TGFβ family ligands such as activin, myostatin and GDF11. Activin plays crucial roles in development, cellular proliferation and apoptosis while myostatin is a known blocker of muscle growth. To identify physiological roles of FSTL3, FSTL3 gene deletion mice (FSTL3 KO) were generated which displayed altered glucose and lipid metabolism phenotypes. To address the role of FSTL3 in cellular biolog...